Our first project is dedicated to the bladder cancer. According
to the NIH statistics, In the United States, bladder cancer is the
fourth most common type of cancer in men and the ninth most common
cancer in women. More than 50,000 men and 16,000 women are
diagnosed with bladder cancer each year.
The bladder cancer is developing in the special tissue called
urothelium. We are working on the first mathematical model of
bladder cancer development. Our multi- level approach is combining
a Cellular Automata model of the cell mutation in the urothelium
with the PDE-based models of oxygen diffusion and angiogenesis – a
tumor-induced growth of the vascular system towards the mutating
cells.
Publications:
E. Kashdan and S. Bunimovich, Multi-scale modeling of bladder
cancer development, accepted for publication in Discrete and
Continuous Dynamical Systems (DCDS) Supplements, 2011
